Inside WHOOP's Wearables AI Engine for Predictive Health

Discover how WHOOP is building an AI-powered health data infrastructure that is redefining how we understand human health. Emily Capodilupo, Senior Vice President of Research, Algorithms, and Data at WHOOP, explains how continuous physiological data is uncovering new opportunities in predictive health through AI, from presymptomatic disease detection to biological age scoring. She examines the governance challenges of deploying AI in a regulated environment and what it takes to build the data trust required to make it work at scale.

Key Moments:

00:57
How WHOOP Built Its AI and Data Foundation
Emily explains how WHOOP's early focus on elite athlete performance shaped the data collection rigor and multidisciplinary science organization that now powers its predictive health capabilities. She outlines the model she built across AI, machine learning, clinical research, and digital signal processing, and why starting with the highest-demand use case created a data foundation built to scale.
06:21
The Power of Continuous Data
Emily draws on WHOOP's sleep research to show how continuous physiological data reveals patterns that would be invisible without longitudinal tracking. She shares findings linking sleep architecture to metabolic disease, cancer risk, and cognitive decline, illustrating why the depth and continuity of a data set determine what insights are actually possible.
13:17
The Data Governance Challenge of Acting on Sensitive Data
Emily shares how WHOOP's respiratory rate data could detect COVID infection up to three days before symptom onset in over 80% of cases, but a denied FDA application left the company holding actionable insights it was legally prohibited from sharing. She examines the governance tension that emerges when your data capabilities move faster than the regulatory frameworks designed to govern them.
27:32
Turning Complex Multi-Signal Data Into a Single Actionable Metric
Emily introduces WHOOP's Healthspan feature, which translates physiological and behavioral data across nine components into a single biological age score tied to all-cause mortality risk. She explains why distilling complex data into one number is more motivating than presenting raw risk statistics, pointing to research that shows how age-based framing drives stronger behavior change.
31:40
Building Data Trust and Privacy Infrastructure at Scale
As WHOOP moves into FDA-cleared products and more sensitive data collection, Emily outlines the governance principles that underpin member trust. She argues that for any organization building on sensitive personal data, the asymmetry between earning trust and losing it should be a foundational design constraint.

Key Quotes: 

Mentions: 

• Harvard Study | Analyzing changes in respiratory rate to predict the risk of COVID-19 infection
• Cornell Study Uses WHOOP Sleep Data to Monitor Patients at Risk for Alzheimer’s
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• There's More to Sleep than Sleep Need: The Importance of Sleep Consistency | WHOOP
• Cribsheet & Expecting Better 2 Books Collection Set By Emily Oster
• The Family Firm: A Data-Driven Guide to Better Decision Making in the Early School Years By Emily Oster

Guest Bios: 

Emily Capodilupo is an award-winning AI and research leader with more than 13 years of experience building and scaling science-driven organizations in fast-paced startup environments. She began her career as an emergency medical technician before studying neurobiology and human sleep at Harvard University and conducting research at Brigham and Women’s Hospital. Emily is driven by a passion for using data to solve hard problems and advance our understanding of human physiology. Along the way, she "accidentally" became a data scientist, recognizing that the biggest breakthroughs in health require not just rigorous science, but big data and bold technology.

As WHOOP’s first employee, Emily founded and now leads the company’s science organization, pioneering a new model of health that begins long before diagnosable illness and is continuous, personalized, AI-powered, and designed to empower individuals to take the driver’s seat in their own well-being. She has built and scaled multidisciplinary teams across artificial intelligence, machine learning, digital signal processing, clinical research, and engineering to translate real-time physiological data into actionable insights that improve performance, resilience, and long-term health. Emily’s work sits at the intersection of wearable technology, digital biomarkers, and predictive health, helping shift healthcare from reactive treatment to proactive optimization.

Music: “The Clermont” by Flash Fluharty
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